[Back to Issue 8 ToC] [Back to Journal Contents] [Back to Biochemistry (Moscow) Home page]

MINI-REVIEW: Inorganic Polyphosphate and Cancer

E. V. Kulakovskaya1, M. Yu. Zemskova1,2, and T. V. Kulakovskaya1,a*

1Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences, 142290 Pushchino, Moscow Region, Russia

2Moscow State Regional University, Research and Education Center of Pushchino, 142290 Pushchino, Moscow Region, Russia

* To whom correspondence should be addressed.

Received April 2, 2018; Revision received April 17, 2018
This review presents data on the relationship between inorganic polyphosphate metabolism and carcinogenesis including participation of polyphosphates in the regulation of activity of mTOR and other proteins involved in carcinogenesis, the role of h-prune protein (human polyphosphatase) in cell migration and metastasis formation, the prospects for using polyphosphates and inhibitors of polyphosphate metabolism enzymes as agents for controlling cell proliferation and migration.
KEY WORDS: inorganic polyphosphates, cancer, metastasis, cell motility, h-prune protein, mTOR

DOI: 10.1134/S0006297918080072