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REVIEW: Mechanisms of Antiphospholipid Syndrome Induction: Role of NKT Cells

S. V. Shirshev1,a

1Institute of Ecology and Genetics of Microorganisms, Perm Federal Research Center, Ural Branch of the Russian Academy of Sciences, 614081 Perm, Russia

Received March 4, 2019; Revised June 3, 2019; Accepted June 3, 2019
The review discusses the mechanisms of participation of natural killer T cells (NKT cells) in the induction of antiphospholipid antibodies (APA) that play a major pathogenetic role in the formation of antiphospholipid syndrome (APS), summarizes the data on APS pathogenesis, and presents modern concepts on the antibody formation involving follicular helper type II NK cells.
KEY WORDS: antiphospholipid syndrome, antiphospholipid antibodies, NK cells, B lymphocytes, humoral immune response

DOI: 10.1134/S0006297919090025