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REVIEW: The Enigma of 2-Cys Peroxiredoxins: What Are Their Roles?

Alexander V. Peskin1,a* and Christine C. Winterbourn1

1Centre for Free Radical Research, University of Otago Christchurch, Christchurch 8140, Otago, New Zealand

* To whom correspondence should be addressed.

Received September 2, 2020; Revised October 9, 2020; Accepted October 9, 2020
2-Cys peroxiredoxins are abundant thiol proteins that react efficiently with a wide range of peroxides. Unlike other enzymes, their exceptionally high reactivity does not rely on cofactors. The mechanism of oxidation and reduction of peroxiredoxins places them in a good position to act as antioxidants as well as key players in redox signaling. Understanding of the intimate details of peroxiredoxin functioning is important for translational research.
KEY WORDS: peroxiredoxin, thiols, redox, signaling, peroxide

DOI: 10.1134/S0006297921010089