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REVIEW: Klotho Protein and Cardio-Vascular System

Ivan N. Tyurenkov1, Valentina N. Perfilova1,a*, Alla A. Nesterova2, and Yelena Glinka3

1Volgograd State Medical University, Ministry of Health of the Russian Federation, 400066 Volgograd, Russia

2Pyatigorsk Medical and Pharmaceutical Institute, Branch of the Volgograd State Medical University, Ministry of Health of the Russian Federation, 357500 Pyatigorsk, Russia

3Keenan Research Centre, St. Michael’s Hospital, Canada, Toronto, ON M5B 1W8

* To whom correspondence should be addressed.

Received April 11, 2020; Revised August 20, 2020; Accepted September 8, 2020
Klotho protein affects a number of metabolic pathways essential for pathogenesis of cardio-vascular diseases and their prevention. It inhibits lipid peroxidation and inflammation, as well as prevents endothelial injury and calcification of blood vessels. Klotho decreases rigidity of blood vessels and suppresses development of the heart fibrosis. Low level of its expression is associated with a number of diseases. Cardioprotective effect of klotho is based on its ability to interact with multiple receptors and ion channels. Being a pleiotropic protein, klotho could be a useful target for therapeutic intervention in the treatment of cardio-vascular diseases. In this review we present data on pharmaceuticals that stimulate klotho expression and suggest some promising research directions.
KEY WORDS: Klotho protein, heart failure, heart ischemia, cardiomyopathy, arterial hypertension

DOI: 10.1134/S0006297921020024