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Neonatal Proinflammatory Stress and Expression of Neuroinflammation-Associated Genes in the Rat Hippocampus

Alexey A. Kvichansky1,a*, Liya V. Tret’yakova1, Maria N. Volobueva1, Anna O. Manolova1, Mikhail Yu. Stepanichev1, Mikhail V. Onufriev1, Yulia V. Moiseeva1, Natalia A. Lazareva1, Alexey P. Bolshakov1, and Natalia V. Gulyaeva1

1Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, 117485 Moscow, Russia

* To whom correspondence should be addressed.

Received February 24, 2021; Revised March 26, 2021; Accepted March 27, 2021
Differential effect of the neonatal proinflammatory stress (NPS) on the development of neuroinflammation in the hippocampus and induction of the depressive-like behavior in juvenile and adult male and female rats was studied. NPS induction by bacterial lipopolysaccharide in the neonatal period upregulated expression of the Il6 and Tnf mRNAs accompanied by the development of depressive-like behavior in the adult male rats. NPS increased expression of the mRNAs for fractalkine and its receptor in the ventral hippocampus of the juvenile male rats, but did not affect expression of mRNAs for the proinflammatory cytokines and soluble form of fractalkine. NPS downregulated expression of fractalkine mRNA in the dorsal hippocampus of juvenile males. No significant effects of NPS were found in the female rats. Therefore, the NPS induces long-term changes in the expression of neuroinflammation-associated genes in different regions of the hippocampus, which ultimately leads to the induction of neuroinflammation and development of depressive-like behavior in male rats.
KEY WORDS: depression, neuroinflammation, cytokines, hippocampus, sex differences

DOI: 10.1134/S0006297921060079