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REVIEW: Current Views on the Role of Stress in the Pathogenesis of Chronic Neurodegenerative Diseases

Leonid G. Khaspekova

Research Center of Neurology, 125367 Moscow, Russia

Received March 5, 2021; Revised April 26, 2021; Accepted April 26, 2021
The review summarizes the results of studies on the cellular and molecular mechanisms mediating the impact of stress on the pathogenesis of neurodegenerative brain pathologies (Alzheimer’s disease, Parkinson’s disease, etc.) and presents current information on the role of stress in the hyperphosphorylation of tau protein, aggregation of beta-amyloid, and hyperactivation of the hypothalamic-pituitary-adrenal axis involved in the hyperproduction of factors that contribute to the pathogenetic role of stress in neurodegeneration. The data on the participation of microglia in the effects of stress on the pathogenesis of neurodegenerative diseases are presented.
KEY WORDS: stress, neurodegeneration, dementia, Alzheimer’s disease, Parkinson’s disease

DOI: 10.1134/S0006297921060110