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REVIEW: Characteristic Features of Protein Interaction with Single- and Double-Stranded RNA

Alexey D. Nikulina

Institute of Protein Research, Russian Academy of Sciences, 142290 Pushchino, Moscow Region, Russia

Received April 29, 2021; Revised June 6, 2021; Accepted June 6, 2021
The review discusses differences between the specific protein interactions with single- and double-stranded RNA molecules using the data on the structure of RNA–protein complexes. Proteins interacting with the single-stranded RNAs form contacts with RNA bases, which ensures recognition of specific nucleotide sequences. Formation of such contacts with the double-stranded RNAs is hindered, so that the proteins recognize unique conformations of the RNA spatial structure and interact mainly with the RNA sugar-phosphate backbone.
KEY WORDS: RNA–protein interaction, single-stranded RNA, double-stranded RNA, RNP domain, ribosomal proteins

DOI: 10.1134/S0006297921080125