AgeMeta: Quantitative Gene Expression Database of Mammalian Aging

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Stanislav Tikhonov^1,2, Mikhail Batin³, Vadim N. Gladyshev⁴, Sergey E. Dmitriev^1,2, and Alexander Tyshkovskiy^1,4,a*

¹Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119234 Moscow, Russia

²Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, 119234 Moscow, Russia

³Open Longevity, 15260 Ventura Blvd, STE 2230, Sherman Oaks, CA 91403, USA

⁴Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA

Received October 12, 2023; Revised December 12, 2023; Accepted February 13, 2024

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AgeMeta is a database that provides systemic and quantitative description of mammalian aging at the level of gene expression. It encompasses transcriptomic changes with age across various tissues of humans, mice, and rats, based on a comprehensive meta-analysis of 122 publicly available gene expression datasets from 26 studies. AgeMeta provides an intuitive visual interface for quantification of aging-associated transcriptomics at the level of individual genes and functional groups of genes, allowing easy comparison among various species and tissues. Additionally, all the data in the database can be downloaded and analyzed independently. Overall, this work contributes to the understanding of the complex network of biological processes underlying mammalian aging and supports future advancements in this field. AgeMeta is freely available at: https://age-meta.com/.

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KEY WORDS: aging, ageing, gene expression, differential expression, transcriptomics, mammalian, meta-analysis, AgeMeta, age-meta, database, GSEA

DOI: 10.1134/S000629792402010X

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