Effect of Cobalt Chloride on Content of Lipids and Lipoproteins in Serum and Liver of Rats

P. A. Kaliman,^1,2 R. V. Shalamov,¹ and A. L. Zagaiko¹

¹Department of Biochemistry, Kharkov State University, pl. Svobody 4, Kharkov, 310077 Ukraine; fax: (0572) 47-18-16; E-mail: malyshev@geron.kharkov.ua

²To whom correspondence should be addressed.

Submitted January 9, 1997; revision submitted March 3, 1997.

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Lipids and the composition of lipoproteins in blood serum and liver cytosol, total lipid, and phospholipid contents in liver subcellular fractions and the spectrum of microsomal liver lipids were studied in male Wistar rats after a single injection of cobalt chloride. Virtually all lipid and lipoprotein fractions in blood and liver were increased and lipoprotein composition was changes. The lipid composition of liver microsomes did not change under these conditions. Thus, microsomal membranes are stable under developing oxidative stress.

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KEY WORDS: cobalt chloride, blood lipids, liver lipids, blood lipoproteins, liver lipoproteins.

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