REVIEW: Kinases of the Src Family: Structure and Functions

A. G. Tatosyan^* and O. A. Mizenina

Institute of Carcinogenesis, Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Kashirskoe Shosse 24, Moscow, 115478 Russia; fax: (095) 324-1205; E-mail: tatosyan@space.ru

^* To whom correspondence should be addressed.

Received September 17, 1999

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Tyrosine kinases of the Src family are involved in different signal transduction pathways in cells. The corresponding genes participate in such vital processes as growth, differentiation, adhesion, transcription, etc. Specific structural changes confer oncogenic properties to the Src protein. In this review, we summarize the available data on the structure, substrates, regulation mechanisms, and role of nonreceptor tyrosine kinases by the example of the src gene product (as the prototype member of this family) and a number of related proteins.

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KEY WORDS: oncogenes, Src, tyrosine kinases, phosphorylation, signal transduction mechanism

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