Protein Content of Human Saliva in Various Psycho-emotional States

I. V. Grigoriev^1*, L. V. Nikolaeva², and I. D. Artamonov²

¹Russian Scientific Center of Rehabilitation and Curortology, Ministry of Public Health of Russian Federation, ul. Novy Arbat 32, Moscow 121099, Russia; fax: (095) 205-2277; E-mail: igor_embs@mail.ru

²Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow 117997, Russia

^* To whom correspondence should be addressed.

Received February 21, 2002; Revision received April 12, 2002

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The protein composition of human saliva depends on psycho-emotional state of individuals. Depression was accompanied by decrease of proteins of molecular masses ranging from 20 to 200 kD, whereas emotionally positive intellectual activity caused the opposite effect. It is suggested that human saliva may be used as an experimental model for the development of diagnostics of various psycho-physiological states.

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KEY WORDS: proteins, saliva, electrophoresis, humans

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