Peptide Derivatives of Antibiotics Tylosin and Desmycosin, Protein Synthesis Inhibitors

N. V. Sumbatyan¹, G. A. Korshunova², and A. A. Bogdanov^1,2*

¹Faculty of Chemistry, Lomonosov Moscow State University, Moscow 119992, Russia

²Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow 119992, Russia; fax: (7-095) 939-3181; E-mail: bogdanov@belozersky.msu.ru

^* To whom correspondence should be addressed.

Received July 1, 2003

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Biologically active peptide derivatives of 16-member macrolide antibiotics were synthesized as potential probes for the investigation of nascent peptide chain topography in the ribosomal exit tunnel. The tylosin and desmycosin aldehyde groups at the C6 position of the lactone ring were modified by the aminooxyacetyl-L-alanyl-L-alanine methyl ester.

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KEY WORDS: antibiotics, macrolides, tylosin, desmycosin, peptide derivatives of macrolides, ribosomal tunnel

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