Protein Structure. Determination, Analysis, and Applications for Drug Discovery (Chasman, D. I., ed., Marcel Dekker, New York-Basel, 2003, 606 p., $195)

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This book consists of four sections, which include 20 chapters written by internationally distinguished authors. The first section, basically an introduction, consists of one chapter. Here the authors discuss interrelationship between structure of proteins and genome organization. They point to our incomplete knowledge of diversity of protein structures in living system. However, a global project now going on will help to make a catalogue of all natural protein structures. Such protein structure inventory maybe achieved on the basis of international cooperation and development of national and international centers for study, systematization, and publication of data on structure of various proteins.

The second section consists of eight chapters, where approaches to production of proteins, crystallization of membrane proteins, and study of protein structures by means of X-ray analysis and NMR-spectroscopy are discussed. Some chapters describe methods of modification of protein structures, including secondary structure.

The third section containing six chapters considers methods of identification of possible errors during design of models of protein tertiary structure. This section also includes a description of the principles of evolutionary classification of protein structures and use of data on protein structure for drug design based on structure of biologically active proteins such as serine proteases, kinases, phosphatases, and their inhibitors. A special chapter in this section introduces the European Bioinformatics Institute (UK, web-site http://www.ebi.ac.uk) founded in 1995. This institute has huge database of protein structures.

The fourth section deals with some problems related to use of structural data for drug design. Particularly, it considers dependence of interferon activity on its structure and mechanisms of action of G-protein coupled receptor family and their structural relationship with rhodopsin.

This book will be useful for biochemists, specialists in bioorganic chemistry, protein structure, and also for biotechnologists and pharmacologists involved in protein structure based drug design.

Doctor of Biological Sciences

G. Ya. Wiederschain

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