REVIEW: Molecular Interactions of Acute Phase Serum Amyloid A: Possible Involvement in Carcinogenesis

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M. A. Vlasova and S. A. Moshkovskii^*

Orekhovich Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Pogodinskaya ul. 10, 119121 Moscow, Russia; fax: (495) 245-0857; E-mail: sergei.moshkovskii@ibmc.msk.ru

^* To whom correspondence should be addressed.

Received April 11, 2006; Revision received May 22, 2006

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Acute phase serum amyloid A (A-SAA) is a well-known marker of inflammation. The present review summarizes data on the regulation of A-SAA expression, signaling pathways which it is involved in, its effects, and possible influences on progression of malignant tumors.

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KEY WORDS: inflammation, malignant tumor, serum amyloid A, NFkappaB, matrix metalloproteinase

DOI: 10.1134/S0006297906100014

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