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REVIEW: Oxidative Stress in Yeast

V. I. Lushchak

Department of Biochemistry, Vassyl Stefanyk Precarpathian National University, 57 Shevchenko Str., Ivano-Frankivsk, 76025, Ukraine; fax: +38 (0342) 714-683; E-mail: lushchak@pu.if.ua

Received December 15, 2008; Revision received October 5, 2009
The mechanisms of production and elimination of reactive oxygen species in the cells of the budding yeast Saccharomyces cerevisiae are analyzed. Coordinative role of special regulatory proteins including Yap1p, Msn2/4p, and Skn7p (Pos9p) in regulation of defense mechanisms in S. cerevisiae is described. A special section is devoted to two other well-studied species from the point of view of oxidative stress – Schizosaccharomyces pombe and Candida albicans. Some examples demonstrating the use of yeast for investigation of apoptosis, aging, and some human diseases are given in the conclusion part.
KEY WORDS: yeast, Saccharomyces cerevisiae, Schizosaccharomyces pombe, Candida albicans, oxidative stress response, regulatory proteins

DOI: 10.1134/S0006297910030041