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Computer Modeling of Transketolase-Like Protein, TKTL1, a Marker of Certain Tumor Tissues

A. O. Maslova1, L. E. Meshalkina2*, and G. A. Kochetov2

1Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, 119991 Moscow, Russia; fax: (495) 939-4195

2Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia; fax: (495) 939-3181; E-mail: luda@genebee.msu.ru

* To whom correspondence should be addressed.

Received September 27, 2011; Revision received November 24, 2011
A computer model of the spatial structure of transketolase-like protein (TKTL1), a marker of certain tumor tissues, has been constructed using the known spatial structure of transketolase found in normal human tissues. The structure of the two proteins at all levels of their organization has also been compared. On the basis of the revealed differences in structures of these proteins, we assume it is unlikely that TKTL1 can be a thiamine diphosphate-dependent protein capable of catalyzing the transketolase reaction.
KEY WORDS: human transketolase, thiamine diphosphate, transketolase-like protein (TKTL1), computer modeling

DOI: 10.1134/S000629791203008X