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Superoxide Scavenging Activity of Plastoquinone Derivative 10-(6′-Plastoquinonyl)decyltriphenylphosphonium (SkQ1)

V. A. Chistyakov1,2*, E. V. Prazdnova2, L. V. Gutnikova2, M. A. Sazykina2, and I. S. Sazykin2

1Rostov State Medical University, Pereulok Nakhichevanskii 29, 344022 Rostov-on-Don, Russia; E-mail: vladimirchi@yandex.ru

2Research Institute of Biology, Southern Federal University, pr. Stachki 194/1, 344090 Rostov-on-Don, Russia; fax: (863) 299-5661

* To whom correspondence should be addressed.

Received April 1, 2012
The plastoquinone derivative 10-(6′-plastoquinonyl)decyltriphenylphosphonium (SkQ1) has the ability to scavenge superoxide anion radical. This ability is manifested both in vitro and in vivo in experiments with the bacterium Escherichia coli. The protective effect of SkQ1 in vivo significantly exceeds that of ascorbic acid.
KEY WORDS: Skulachev ions, SkQ1, superoxide anion radical, superoxide scavenging activity, E. coli

DOI: 10.1134/S0006297912070103