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REVIEW: MicroRNAs: Possible Role in Pathogenesis of Parkinson’s Disease

E. V. Filatova, A. Kh. Alieva*, M. I. Shadrina, and P. A. Slominsky

Institute of Molecular Genetics, Russian Academy of Sciences, 2 Kurchatov Sq., 123182 Moscow, Russia; fax: (499) 196-0210; E-mail: anelja@img.ras.ru

* To whom correspondence should be addressed.

Received March 29, 2012
Parkinson’s disease is one of the most common human neurodegenerative disorders caused by the loss of dopaminergic neurons from the substantia nigra pars compacta of human brain. However, causes and mechanisms of the progression of the disease are not yet fully clarified. To date, investigation of the role of miRNAs in norm and pathology is one of the most intriguing and actively developing areas in molecular biology. MiRNAs regulate expression of a variety of genes and can be implicated in pathogenesis of various diseases. Possible role of miRNAs in pathogenesis of Parkinson’s disease is discussed in this review.
KEY WORDS: microRNA, Parkinson’s disease, miRNA-dependent regulation

DOI: 10.1134/S0006297912080020