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REVIEW: Human Herpes Simplex Virus: Life Cycle and Development of Inhibitors

M. K. Kukhanova, A. N. Korovina*, and S. N. Kochetkov

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, ul. Vavilova 32, 119991 Moscow, Russia; E-mail: kukhan86@hotmail.com; anna.korovina@gmail.com; kochet@eimb.ru

* To whom correspondence should be addressed.

Received May 19, 2014
WHO reports that 90% of human population is infected by different types of herpesviruses, which develop latency or cause oral and genital herpes, conjunctivitis, eczema herpeticum, and other diseases. Herpesvirus almost always accompanies HIV-infection and complicates AIDS treatment. Herpes simplex virus type 1 is one of the most wide spread viruses from the Herpesviridae family. HSV virion, genome structure, replication mechanisms, antiherpes drug development strategies, including design of prodrugs, and mutations causing ACV-resistance in clinical HSV isolates are discussed in this review.
KEY WORDS: HSV, herpes simplex, life cycle, replication, drugs, mutations, resistance

DOI: 10.1134/S0006297914130124