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REVIEW: Bacterial Small Regulatory RNAs and Hfq Protein

V. N. Murina* and A. D. Nikulin

Institute of Protein Research, Russian Academy of Sciences, 142290 Pushchino, Moscow Region, Russia; E-mail: thyrada@rambler.ru

* To whom correspondence should be addressed.

Received June 25, 2015
Small regulatory RNA (sRNA) is a unique noncoding RNA involved in regulation of gene expression in both eukaryotic and bacterial cells. This short review discusses examples of positive and negative translation regulation by sRNAs in bacteria and participation of Hfq in these processes. The importance of structure investigation of nucleotide–protein and RNA–protein complexes for designing a model of Hfq interaction with both mRNA and sRNA simultaneously is demonstrated.
KEY WORDS: Hfq, small regulatory RNA, sRNA, RNA–protein recognition, regulation of gene expression

DOI: 10.1134/S0006297915130027