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REVIEW: Amyloid Properties of Titin

E. I. Yakupova1,2*, I. M. Vikhlyantsev1,2*, M. Y. Lobanov3, O. V. Galzitskaya3, and A. G. Bobylev1,2*

1Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, 142290 Pushchino, Moscow Region, Russia; E-mail: yakupova.mira@mail.ru, ivanvikhlyantsev@gmail.com, bobylev1982@gmail.com

2Pushchino State Institute of Natural Sciences, 142290 Pushchino, Moscow Region, Russia

3Institute of Protein Research, Russian Academy of Sciences, 142290 Pushchino, Moscow Region, Russia

* To whom correspondence should be addressed.

Received February 27, 2017; Revision received May 23, 2017
This review considers data on structural and functional features of titin, on the role of this protein in determination of mechanical properties of sarcomeres, and on specific features of regulation of the stiffness and elasticity of its molecules, amyloid aggregation of this protein in vitro, and possibilities of formation of intramolecular amyloid structure in vivo. Molecular mechanisms are described of protection of titin against aggregation in muscle cells. Based on the data analysis, it is supposed that titin and the formed by it elastic filaments have features of amyloid.
KEY WORDS: amyloids, amyloidoses, titin, functional amyloids

DOI: 10.1134/S0006297917130077