REVIEW: Role of Nuclear Lamina in Gene Repression and Maintenance of Chromosome Architecture in the Nucleus

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Y. Y. Shevelyov^1* and S. V. Ulianov^2,3

¹Institute of Molecular Genetics, Russian Academy of Sciences, 123182 Moscow, Russia; E-mail: shevelev@img.ras.ru

²Institute of Gene Biology, Russian Academy of Sciences, 119334 Moscow, Russia

³Lomonosov Moscow State University, Faculty of Biology, 119192 Moscow, Russia

^* To whom correspondence should be addressed.

Received November 20, 2017; Revision received December 5, 2017

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Nuclear lamina is a protein meshwork composed of lamins and lamin-associated proteins that lines the nuclear envelope from the inside and forms repressive transcription compartment. The review presents current data on the contribution of nuclear lamina to the repression of genes located in this compartment and on the mechanisms of chromatin attachment to the nuclear envelope.

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KEY WORDS: nuclear lamina, lamina-associated domain, nuclear envelope, nuclear periphery, repression

DOI: 10.1134/S0006297918040077

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