REVIEW: Effect of Environmental Factors on Nuclear Organization and Transformation of Human B Lymphocytes

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F. B. Sall^1,2,3#, D. Germini^1,2#, A. P. Kovina^1,2,4, V. Ribrag^5,6, J. Wiels^1,2, A. O. Toure³, O. V. Iarovaia^2,4, M. Lipinski^1,2, and Y. Vassetzky^1,2,7*

¹UMR8126, Université Paris-Sud, CNRS, Institut de Cancérologie Gustave Roussy, 94805 Villejuif, France; E-mail: vassetzky@igr.fr, vassetzky@gmail.com

²LIA1066 “Laboratoire Franco–Russe de Recherche en Oncologie”, 94805 Villejuif, France

³Laboratoire d’Hématologie Centre Hospitalier Universitaire Aristide Le Dantec, Université Cheikh Anta Diop, Dakar, Sénégal

⁴Institute of Gene Biology, Russian Academy of Sciences, 119334 Moscow, Russia

⁵Institut Gustave Roussy, 94805 Villejuif, France

⁶Institut National de la Santé et de la Recherche Médicale (INSERM) Unité (U) 1009, Université Paris Sud, Institut Gustave Roussy, 94805 Villejuif, France

⁷Koltzov Institute of Developmental Biology, Russian Academy of Sciences, 119334 Moscow, Russia

^# These authors contributed equally to this work.

^* To whom correspondence should be addressed.

Received November 10, 2017; Revision received December 8, 2017

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Chromosomal translocations have long been known for their association with malignant transformation, particularly in hematopoietic disorders such as B-cell lymphomas. In addition to the physiological process of maturation, which creates double strand breaks in immunoglobulin gene loci, environmental factors including the Epstein–Barr and human immunodeficiency viruses, malaria-causing parasites (Plasmodium falciparum), and plant components (Euphorbia tirucalli latex) can trigger a reorganization of the nuclear architecture and DNA damage that together will facilitate the occurrence of deleterious chromosomal rearrangements.

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KEY WORDS: Burkitt lymphoma, EBV, HIV, Plasmodium falciparum, Euphorbia tirucalli, oncogenesis, nuclear organization

DOI: 10.1134/S0006297918040119

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