REVIEW: Structure and Functions of the Mediator Complex

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E. V. Putlyaev¹, A. N. Ibragimov¹, L. A. Lebedeva¹, P. G. Georgiev¹, and Y. V. Shidlovskii^1,2*

¹Institute of Gene Biology, Russian Academy of Sciences, 119334 Moscow, Russia; E-mail: yul.biogen@gmail.com

²Sechenov First Moscow State Medical University, 119048 Moscow, Russia; E-mail: expedition@mma.ru

^* To whom correspondence should be addressed.

Received October 31, 2017; Revision received December 4, 2017

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Mediator is a key factor in the regulation of expression of RNA polymerase II-transcribed genes. Recent studies have shown that Mediator acts as a coordinator of transcription activation and participates in maintaining chromatin architecture in the cell nucleus. In this review, we present current concepts on the structure and functions of Mediator.

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KEY WORDS: Mediator, transcription, RNA polymerase, chromatin, enhancer, promoter

DOI: 10.1134/S0006297918040132

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