2Sechenov First Moscow State Medical University, 119048 Moscow, Russia; E-mail: firstname.lastname@example.org
* To whom correspondence should be addressed.
Received October 31, 2017; Revision received December 4, 2017
Mediator is a key factor in the regulation of expression of RNA polymerase II-transcribed genes. Recent studies have shown that Mediator acts as a coordinator of transcription activation and participates in maintaining chromatin architecture in the cell nucleus. In this review, we present current concepts on the structure and functions of Mediator.
KEY WORDS: Mediator, transcription, RNA polymerase, chromatin, enhancer, promoter