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REVIEW: Role of NUDIX Hydrolases in NAD and ADP-Ribose Metabolism in Mammals

V. A. Kulikova1,2,3,a* and A. A. Nikiforov2

1Peter the Great St. Petersburg Polytechnic University, 195251 Saint Petersburg, Russia

2Institute of Cytology, Russian Academy of Sciences, 194064 Saint Petersburg, Russia

3Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, 194223 Saint Petersburg, Russia

* To whom correspondence should be addressed.

Received April 29, 2020; Revised June 21, 2020; Accepted June 22, 2020
Proteins of the NUDIX hydrolase (NUDT) superfamily that cleave organic pyrophosphates are found in all classes of organisms, from archaea and bacteria to higher eukaryotes. In mammals, NUDTs exhibit a wide range of functions and are characterized by different substrate specificity and intracellular localization. They control the concentration of various metabolites in the cell, including key regulatory molecules such as nicotinamide adenine dinucleotide (NAD), ADP-ribose, and their derivatives. In this review, we discuss the role of NUDT proteins in the metabolism of NAD and ADP-ribose in human and animal cells.
KEY WORDS: NUDIX hydrolases, NAD, ADP-ribose, metabolism

DOI: 10.1134/S0006297920080040