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REVIEW: Drug-Related Carcinogenesis: Risk Factors and Approaches for Its Prevention

G. A. Belitskiy1, K. I. Kirsanov1,2,a*, E. A. Lesovaya1,3, and M. G. Yakubovskaya1

1Blokhin Russian Cancer Research Center, Ministry of Health of Russian Federation, 115478 Moscow, Russia

2Peoples’ Friendship University of Russia, 117198 Moscow, Russia

3Pavlov Ryazan State Medical University, 390026 Ryazan, Russia

* To whom correspondence should be addressed.

Received April 24, 2019; Revised July 11, 2019; Accepted July 19, 2019
The review summarizes the data on the role of metabolic and repair systems in the mechanisms of therapy-related carcinogenesis and the effect of their polymorphism on the cancer development risk. The carcinogenic activity of different types of drugs, from the anticancer agents to analgesics, antipyretics, immunomodulators, hormones, natural remedies, and non-cancer drugs, is described. Possible approaches for the prevention of drug-related cancer induction at the initiation and promotion stages are discussed.
KEY WORDS: therapy-related carcinogenesis, secondary tumors, cancer prevention

DOI: 10.1134/S0006297920140059