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REVIEW: Electroanalysis of Biomolecules: Rational Selection of Sensor Construction

Victoria V. Shumyantseva1,2,a*, Lubov E. Agafonova1, Tatiana V. Bulko1, Alexey V. Kuzikov1,2, Rami A. Masamrekh1,2, Jiayin Yuan3, Dmitry V. Pergushov4, and Larisa V. Sigolaeva1,4

1Laboratory of Bioelectrochemistry, Orekhovich Research Institute of Biomedical Chemistry, 119992 Moscow, Russia

2Department of Biochemistry, Pirogov Russian National Research Medical University, 117997 Moscow, Russia

3Department of Materials and Environmental Chemistry, Stockholm University, 10691 Stockholm, Sweden

4Faculty of Chemistry, Lomonosov Moscow State University, 117991 Moscow, Russia

* To whom correspondence should be addressed.

Received November 10, 2020; Revised November 18, 2020; Accepted November 18, 2020
Methods of electrochemical analysis of biological objects based on the reaction of electro-oxidation/electro-reduction of molecules are presented. Polymer nanocomposite materials that modify electrodes to increase sensitivity of electrochemical events on the surface of electrodes are described. Examples of applications electrochemical biosensors constructed with nanocomposite material for detection of biological molecules are presented, advantages and drawbacks of different applications are discussed.
KEY WORDS: electroanalysis, multi-walled carbon nanotubes, biosensors, label-free detection, DNA, heme proteins

DOI: 10.1134/S0006297921140108