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REVIEW: Mitochondrial Production of Reactive Oxygen Species

V. G. Grivennikova* and A. D. Vinogradov

Department of Biochemistry, Biological Faculty, Lomonosov Moscow State University, 119991 Moscow, Russia; E-mail: vgrivennikova@mail.ru; adv@biochem.bio.msu.su

* To whom correspondence should be addressed.

Received June 18, 2013
Numerous biochemical studies are aimed at elucidating the sources and mechanisms of formation of reactive oxygen species (ROS) because they are involved in cellular, organ-, and tissue-specific physiology. Mitochondria along with other cellular organelles of eukaryotes contribute significantly to ROS formation and utilization. This review is a critical account of the mitochondrial ROS production and methods for their registration. The physiological and pathophysiological significance of the mitochondrially produced ROS are discussed.
KEY WORDS: oxidoreductases, respiratory chain, ROS production, mitochondria

DOI: 10.1134/S0006297913130087